First make a character model, make take a few minutes to a few hours. It's all up to you
Go through the prologue and visit your baby
Meet with the Vault- Tec guy and fill out your S.P.E.C.I.A.L attributes, and name your player
Find the Vault Entrance and the pip boy and open the door
Make any changes you'd like and leave the vault
As soon as you can find Hubris comics, be careful.
You should find a place like this, enter and clear the area
Reach the top floor and you should find a studio, come back here and find Gornaks Outfit and put it on
Next travel to Duneich borers, be prepared there are tough enemies here.
Go as far down into the quarry as you can till you find this hole with water. Go in it
Find this table with mini nukes and pick up the weapon.
Upgrade the BIG LEAGUES perk to the max, this make take a while because you need other perks and levels
And combined, you will be hacking and slashing your enemies in minutes